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The city of Columbia, Pennsylvania (on the Susquehanna) was considered a potential spot for the capital of the United States. Wiki says it was just a few votes short of becoming the capital.
As a city just up river from the Chessapeake Bay (and thus the southern states of Maryland and Virginia) it seems like a decent compromise option between the North and the South. Not to mention its more western location would work out somewhat nicely in a nation pushing west at the time.
So what if Columbia had been where the capital was stuck?