With a POD in the 18th century, early enough, perhaps a new Dominion of New England surfaces? It could encompass Pennsylvania and Delaware and probably Marland as well, and eventually move into the Ohio Valley and beyond.
I'm not sure how that would be done, though. It would have to have looser restrictions on trade than the previous since IIRC the economy was the main problem witht he frist, as it was hurting their merchants and making the British ones richer.
Perhaps if this were coupled with a French victory in the French and Indian Wars, the Dominion of New England could then merge with the large Louisiana when *it* rebels, if it does. Not right away but eventually.