After the death of Lorenzo de' Medici (1492), Papal State bring Tuscany. Than, Pope Alexander VI, put his son Giovanni Borgia on the throne of Naples. The other son, Cesare Borgia, occupy the northern duchies, Milan and Turin. Starts to be a federation of Italian States under lead by the Pope. The federation is joined by Republics of Venice and Genoa too. Italy, therefore, starts to be a Federeation lead by the Pope at the end of XV century-start of the XVI.
What would happen?