Thomas Howard's first wife was Anne of York, one of the younger sisters of Henry VIII's mother, Elizabeth of York. Ultimately she didn't end up the mother of his heir, Henry Howard, Earl of Surrey. Thomas and Anne had at least one son, Thomas Howard who lived between 1496 – 1508 and the existence of other children are contested. Suppose he makes it to adulthood or has other brothers who do and they or he has sons.
How do things change if Thomas Howard's heir is a grandson of Edward IV? Is the family likely to run afoul of Henry VIII much earlier? Will Norfolk still support his niece, Anne Boleyn? If he or his heirs are protestant, do they Edward IV would look to his Howard cousin instead of Lady Jane Grey?