Thomas Dewey Assassinated

Gangster Dutch Schultz tried to put a hit out on Dewey in 1935 but the Commission denied him so Schultz went out on his own and was eventually killed himself due to his reckless hit.

My question is what would have happened to American crime if the Commission had said yes and Murder inc. rubbed Dewey out?
 
One of the ironies of that is that Lucky Luciano was the one who ordered Shultz to be killed, and robbed of his first target Dewey then shifted his focus to Lucky
 
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