Repatative Civil Wars? Not likely.
Most likely the best chances would be hard to do in real life because some of them go against common sense of national politics. Though a good chance would be to Keep the Articles of Confederation or less Centralized in some aspects and buying the Louisiana purchase and just contunue to have settlers moving outwest.
At some point the eastern states start to fight things out which causes the Mississippian states to distance themselves from the east and something similar with the Pacific untill a point of De facto or De Jure independance.