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Let's say there's a timeline in which for some reason the South Americans have similar tech to Europeans and they are immune to European diseases. The invasions takes place in the late 1700s. How long would the Spanish Empire or the Spanish and Portuguese people be able to hold onto the region? In perpetuity like in OTL? Perhaps just 5 decades?
In this scenario the Spanish and Portuguese get 40 years before the French rock up and start tipping resources into resistance movements. The Spanish treat the South Americans with the same level of brutality as OTL.