Here we have a major shift, in these last two installments. The Ptolemaic Empire is losing its northernmost territories, while at the same time Rome has taken southern Italy, and Rome and Carthage are moving in on Sicily. If Rome and Carthage succeed, the two (potentially powerful) allies, the Massalian League and the Ptolemaic Empire, will be divided. Rome and Carthage will force themselves in between al west-east trade across the sea, profiting from that. Additionally, all this may drive the Ptolemaic Empire to expand more to the south (aiming for Indian trade), while the Massalian League could decide to refocus on expansion in the west (western Europe and northwestern Africa).
And then there's still the Iberian question. Hannibal probably wants that back. If the Rome-Cathage alliance can isolate Massalia from allies in the east, the next step should probably be to force Massalia into a multi-front war. Essentially, Cathage would attack Iberia, using the minimized Barcid state as a staging zone, while Rome attacks Massalia more directly. Additionally, the Rome-Carthage alliance could try to make the Iberian insurgents into allies, promising them independence if they rise up against the League at that exact time as well.
It would be quite tricky for Massalia to fight off such an attack.