I would differentiate between macro changes (which should be harder to put in place, given the inertia of history, but easier to predict) and mini changes, which are in practice unpredictable.
After a generation at most, I would expect that the cumulative effect of mini changes would be such as to make it almost impossible to predict anything with accuracy.
I would assimilate a TL to a simplified mathematical model, which can predicts future behaviors but with significant in-built limitations.
And obviously there is no way to predict the future if the POD is significant enough (you cannot predict the behavior of a mathematical function after a cusp). An example (maybe not completely accurate) taken from OTL is the sudden diffusion of mobile phones, which in a very short time have significantly changed our behavior.
Would anyone bet that no Einstein or Leonardo Da Vinci was born in the last 10 years just because boy and girl could meet having access to mobile phones? Or, by the same token, that he/she was not conceived due to a fall out originated by a mobile conversation?
Sorry, forgot the main point: no one ever predicted the explosion of mobile use, and the associated behaviors!