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IOTL Isabella I of Castile and Ferdinand II of Aragon had five children who survived to adulthood, four of them were daughters and just one a son (the unlucky John, Prince of Asturias).

So, I was playing with this idea: WI the situation had been the inverse, and the couple has four sons and only one daughter? Just to make it easier for reference, I'll give some names: John (replacing the IOTL Isabella, Queen of Portugal ), Isabella (instead of John, Prince of Asturias), Peter (Joanna of Castile), Alfonso (Maria, Queen of Portugal) and Ferdinand (Catherine, Queen of England).

So, what could happen under this situation. I assume that their only daughter would be married to a Portuguese royal, given the political needs of the time and the fact that IOTL Isabella was twice sent to Portugal and later her sister was also queen there. Of course, no Habsburg inheritance is a given, but some sort of alliance with them is still likely.

I assume that at least one of their sons would be educated to have a religious life, but could the Trastamara domains be divided again in order to give them crowns (as the eldest receiving Castile, other Aragon, perhaps one of them Sicily)?

And who could be the alternate brides for Philip the Handsome and prince Arthur (and probably later Henry VIII)?
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