The kingdom of Naples isn't conquered by the Spanish

With a POD between 1495 and 1501, how could the independence of the kingdom of Naples be saved, avoiding its conquest by the Spanish? Making Ferdinand II of Naples live longer would be enough, or other changes are also necessary?
 
IMO you'd need to go further back than this. If you have René d'Anjou hold Naples against Alfonso V, and there's every likelihood that he'll move his capital there - King of Naples is better than Duke of Provence, after all. This would leave Sicily in Aragonese hands, and possibly eventually Spanish, but with a firm claim on the island from the Kingdom next door.
 
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