The impact if Indians and Chinese had similar immunity to European diseases as the Americans?

How would have colonization have gone had Indians and Chinese lacked the immunity to Europeans diseases that the indigenous Americans did?
 
How would have colonization have gone had Indians and Chinese lacked the immunity to Europeans diseases that the indigenous Americans did?

How would you do this? India and China have had smallpox as long as Europe has had it.
 
This is terribly implausible. About the only way that would be possible would be if civilization never developed in India and China, or collapsed early, or if nothing diffused east from the Middle East.

And the consequences if Asia was depopulated during the 16th century? Well, they would be dire for the entire world. Without India and China as trading partners, to name one example, how would the Spanish and Portuguese empires be viable?
 
I think Europeans had immunity to certain diseases in the same way Africans had to malaria. They got it as kids and either survived or died. While Africans and pre-Colombian Americans showed signs of being less effected by certain diseases, I feel that the infant mortality thing is important. Locals also knew to avoid certain areas. Englishmen built Jamestown on an area without fresh water and surrounded by swamps with mosquitos, which the local tribes avoided due to... Well, the chance of death and mosquitos. During the American Revolution there was an outbreak of smallpox that a book I read in the past said matched or surpassed the death toll by fighting. Didn't check their sources, though. Anyways, that reminds me about inoculations. And how Abigail Adams had one for smallpox but refused to stay out of the public, walking around others for weeks before going to seclusion to be cared for. Presumably in middle-class splendor.

https://en.m.wikipedia.org/wiki/1775–82_North_American_smallpox_epidemic
 
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