I do agree they'd act like Trebizond as a peripheral nation of ere if it was powerful. But we're near the end of the ere with the Ottomans and other Europeans all trying to break it. Even if it's salvaged by a really competent and lucky emperor there should be friction between the two nations at first.I would guess that rather that 'rival' they would probably, (that once stabilized and secured their independency/rulership), that it come to be similar to the byzantine successor/splinted states like Trebizonde, Epirus or Nicaea but with politicals, geographical and on manpower, quite uniques advantages.
Well, while I think that they should consider and weight carefully any possible marriage links/alliances that would force them to be too involved in the Italian affaires.
But about their possible foreign interests...
And speculating, I tend to think that once the Sicilian Vatatzés, could divert their attention from the present pressing situation, that Greece (Achaia) and especially Epirus and Cefalony, would after Naples, will be in the center of their attention.
Perhaps, acting there, taking advantage of their double condition of Sicilian rulers with the interest of their own to fight against any Angevin influence and/or foreign intervention... But with, the key difference, that possibly they would have the 'Byzantine legitimacy' (for the local inhabitants) and/or that they would be acting there, (at least, they could claim it) in behalf of the Empire...
Finally, I wouldn't discard that eventually, the Sicilian Despotate could eventually be regarded as the one that for the Byzantines filled the same or similar role that Isauria had for the Empire in the past...
But yeah I agree that the Syracuse despotate could be seen as one of the places where the empire pops back up. I just think in the short term the palailogos would just be too insecure to see the Vatatzes as allies until they're strong enough because the vatatzes are strong and rising in power while having the legitimacy of force and bloodline to claim every part the palailogos claim, including mainland Greece at least.
But I do think the main thing the despotate would be thinking about is Naples. Considering their proximity and past I do think the main objective of the despotate is to stay alive and strengthen their hold of the lands they control, and expand if possible.
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