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I read an AAR on EU III recently where a player managed to conquer most of North America as the Iroquois and fend off the Portuguese. Then I was reading works like Lands of Ice and Mice/Lands of Red and Gold got me to wondering, how possible would it be for a functioning nation or resistance be to hold out in the Americas against European colonisation? What would you have to change?
I'm thinking not just a surviving rump state like there was in Vilcabamba (https://en.wikipedia.org/wiki/Neo-Inca_State) but also ones that can compete with the invaders or at least slow their progress westward more so than it happened in OTL. The colonisation of the Americas is not an area I've studied much in detail so I welcome reading recommendations in addition to the discussion.