The Republic of West Florida had a chance to exist as a state but it essentially got carved up and taken piecemeal, meaning the local Americans that moved in upon Spanish annexation in 1783 (the loyalists essentially left en masse to the West Indies with other southern loyalists) never had a chance to (re-)develop a strong local identity and translating that into local governance:
1) an attempt was made to get Mobile to revolt with St. Francisville in the West Florida revolt, but failed. The successful but paltry-sized St. Francisville area was annexed to Louisiana.
2) Mobile was eventually taken on its own by American forces. Annexed to Alabama so it'd have a port.
3) The remaining traditional bit of West Florida, Pensacola, was sold wholesale with East Florida despite Spain explicitly selling both Floridas. It just got lumped in with the now-singular Florida.
If Mobile revolts with St. Francisville, West Florida big enough to be taken seriously. It's not inconceivable America accepts its annexation as a state, claims to at least the 1763 colony borders or even 1765 ones, forces Mississippi Territory to drop claims to it, and de-facto annex Pensacola to it when Andrew Jackson takes over the city and formally upon the Adams-Onis Treaty.