alternatehistory.com

Annoyingly, we still don't know whether Syphilis originated in the Americas, and was returned to the Old World by Columbus' first voyage. We may never actually know.

....But we do know some things. Things that may be relevant to Alternate Histories of the Americas.

There's seems to be room to speculate about pre-Colombian, intra-American epidemic diseases, and this without first hand-waving new domesticated species into being.
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