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From what I can gather, when FDR was planning the United States' initial 'preparedness actions' prior to the Second World War, he was determined to make the war effort, should one take shape, a bipartisan affair, leading to his appointing of former Secretary of State Henry L. Stimson to the post of Secretary of War and former Republican Vice Presidential nominee Frank Knox to the post of Secretary of the Navy shortly before the outbreak of the war.

Reportedly, Roosevelt was leaning towards choosing his personal ally, the Republican Mayor of New York City, Fiorello La Guardia for Secretary of War, but ultimately went for Stimson because of his record in previous administrations.

What if he hadn't, and La Guardia became the United States' Secretary of War for the duration of World War II?
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