San Miguel de Gualdape - Spanish North America

I'm surprised this premise hasn't come up as much as it has, but what if the Spanish settlement known as San Miguel de Gualdape survived? Located somewhere near Georgetown in what is present day South Carolina (though this is up for debate), the settlement was an attempt by the explorer and sugar plantation owner Lucas Vázquez de Ayllón to tap into the unclaimed resources of North America, establishing a small village on the coast in 1526 with the help of 600 settlers and a number of African slaves. However, like so many other European attempts at North American settlement during this period, the small colony essentially fell apart over a very short period of time to disease, famine, infighting, troubles with the local Amerindians, and the first slave revolt in North American history, de Ayllón dying during the course of a particularly harsh winter, his successor Francis Gomez being forced to abandon settlement and take the remainding 150 survivors to Hispaniola.

What if the settlement had survived?
 
The British burn it to the ground at some point. Or the French do.

The easier wealth of Central/South America/the Carribean would have far more appealing to Spanish colonists, so I don't see a reason why the colony would beget new ones. On the other hand, they might create a native-alliance to back them up, thanks to their more lenient views on race-mixing AIUI.
 
Spanish NorthAmerica

Perhaps having achieved the interest of the Church or any part thereof as the Jesuits (involving automatic interest of the crown) as a missionary base from which missionaries would relate to the natives and would improve the livelihood of the colony, which would be protected '' be burned to the ground '' for some European enemy of Spain, at first, because during the sixteenth century Hispanic American fleet was unbeatable in water.
Then by the same expansion of the colony to develop and build defenses as other Caribbean colonies fortified Spanish and finally by the European disinterest in attacking a colony with no strategic value and possessed no gold or silver
to loot, to offset the costs of putting together an expedition to conquer and endure inevitable Spanish retribution for the attack.

It would be consequences that the Spanish colonizers axis in Georgia and Florida, it would in the Atlantic with a series of enclaves along the coast (embryos of future colonies.
The evangelization of the Native (task in which the Spaniards were very competent) would be the basis of their assimilation and integration (cultural and physical) to Community
Hispanic, constituting itself into a protective barrier from northern Georgia to the Gulf of Mexico; Hispanic-Indigenous mixed settlements against other native and / or Europeans.
Even though because of the future weakness of the Spanish Empire be conquered, the Spanish-Indian cultural imprint of the Region, preserved and disseminated by the Church, may be submerged but their socio-cultural roots would irreversibly Hispanic and Catholic.
It is likely that the rebellion of the North American colonies of England does not happen with another hated enemy Papist, '' Roman scheming instrument '' in the south after the defeat of the French, to continue to need the protection of the royal troops in colonies and maintenance, at least in the southern colonies.​
 
That's not the only Colony. There was an attempted colony in the Chesapeake, Ajacan. It was originally a failed Christianization attempt of the Virginia Peninsula, and it predated Jamestown by something like 40 years or so. They called the Chesapeake "Bahía de Madre de Dios" or "Bahía de Santa Maria". They landed in Virginia and named in Ajacan, as in Ore. I don't think hey founded any settlements, but they probably could have,
 
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