Reverse the Era of Good Feelings

The Era of Good Feelings was an era in USA politics were the Democratic-Republican party was the only political party with any significant power. What would the USA be like if this was reversed, if instead of the Democratic-Republicans gaining all the political power they lost all of their power, and the Federalist Party became the only party that had power?
 
Alexander Hamilton would have to stay alive (and not discredited), there can't be a War of 1812, and there should probably be a Southern secession movement that gets revealed in a manner analogous to the Hartford Convention.
 
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