Regarding a marriage of Anne of Navarre and Henry VIII

From what I read, her first husband who died in 1528 in the Battle of the League of Cognac, she died as a childless widow - her obstetric record is similar to Margaret of Austria(the widow of John of Asturias), this means a marriage with her with Henry VIII can end up as identical to Anne Boleyn or Catherine of Aragon, although her youngest sister, Isabella is very much fertile..
 
Modern studies have suggested that were not his wives, but same Henry (and with him the Tudors) the cause of the low fertility due to clinical/genetic problem/disorder.
can be changed the wives, but (probably) Henry would equally condemned to a lifetime of desperately seeking of a male heir.
 
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