So Rome's surrendered, not sacked? Unless he put some harsh conditions on Rome, they're going to come back as soon as possible, when Pyrrhus is off trying to conquer Macedonia or Carthage or something, and will take Magna Graecia - which Pyrrhus wouldn't care about until after he's bitten off more then he can chew somewhere else. Pyrrhus was a talented general, but... not talented enough to conquer like he did IOTL.
The PoD requires Pyrrhus to actually finish a campaign. I always like a successful siege of Lilybaeum - IOTL, it was the last Punic city left in Sicily, but when his fleet was lost, Pyrrhus demanded a new fleet, but abandoned the siege anyways, losing all of his won love in Sicily. Now, he'd have to control his urges and not invade Carthage like he probably wanted to IOTL, wanting to better Agathocles, but if he did, it would be in time for him to come back and fight Rome in the same year he did IOTL, and he'd probably have more men, more money, and Sicily on his side - he has claims to the Syracusan throne, as his son Alexander is Agathocles' grandson. Sicily's a fickle place, but if Pyrrhus can get Alexander established, I think there's a chance it could stay under Epirot control.
If Pyrrhus manages to keep an empire consisting of Epirus, Sicily, and Magna Graecia, I think he could take Greece, Rome, or even Carthage if he wanted to - probably not all three, and any one of those would be hard to control after his death, especially with Sicily and Tarentum, but I think he could has a chance to conquer any of them.
The ramifications defend on the scenario. If he doesn't conquer Carthage at some point, it could be a Carthage wank, with Rome out of the way. Could be an early Rome wank, if Pyrrhus keeps Rome strong enough to fight him again, and he gets caught up in some capaign far away. Or he could establish Macedonian and Sicilian kingdoms with his sons Ptolemy and Alexander, both of which would have potential.