This was the case for a time in some places in Tennessee after statewide Prohibition (a few years before National Prohibition) when the mayors of Nashville (Hilary Howse) and Memphis (the famous "Boss" E. H. Crump) refused to enforce Prohibition. Howse's statement on protecting saloons was "Protect them? I do better than that. I patronize 'em." This issue had split the Democrats (a state politician coincidentally named D.B. Cooper had a gun battle in the streets of Nashville with another state politician, Edward Carmack, editor of The Tennesseean, resulting in the latter's death) and let the Republicans gain a huge amount of power in the state during the Solid South era, with the two-term Republican governor Ben W. Hooper. Governor Hooper and the state courts essentially forced Howse and Crump to resign, but both men returned in the years to come (and ensured illegal saloons plus gambling operations stayed open in their cities) thanks to the networks they built which in large part depended on poor urban voters both black and white, and one key way of gaining support (used for decades later in Tennessee) was to have the police confiscate liquor and have the same police distribute it in precincts which needed some "greasing of the palms" during elections for favoured candidates.
Based on this, it's likely the temperance interests combined with political enemies of these politicians will interfere as much as possible. Any pretext to remove a politician will be used, and given how many local and state governments flirted with illegal practices, there's plenty of pretexts available. And for anti-temperance politicians, why not go the "Baptists and bootleggers" route and have your supporters pass out confiscated liquor to potential voters? And don't forget the federal government's ability to withhold funds, as famously done with how they refused highway funds to states which didn't raise the drinking age to 21. Overall a more instable and corrupt political landscape in the US.