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In a POD where James VI & I of Scotland and England dies before he has any children with Anne of Denmark, either murdered or due to natural causes, or otherwise dies in childbirth with his mother Mary of Scots, what would be the consequences to the political scene of the British Isles and Europe in a whole?

Although we all know that marriage/inheritance played a great part at the political games of that time, let's not forget that the Isles were through a delicate period: the Anglican Communion, the clashes between Protestants and Catholics, clashes between factions of Protestants, Scotish calvinists/presbyterians, and tons of conspiracies from all sides. Not to even mention the international politics: the raving-mad Habsburgs from Austria and Spain, the decadent Valois from France, the arise of Scandinavian protestantism, the exploration of North America and so on.

Elizabeth dies 1603 as IOTL. No James Stuart. No Union of Crowns. Who would inherit Scotland? Who would inherit England and Ireland? Would the Isles still be strong in their Protestant cause? Would Catholics take over?

Well, it's up to you.
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