Plausibility of a successful native revolt in Spanish America?

Was there at any point during the rise of Spain's colonial Empire in the America's that the native peoples could have possibly risen up and thrown off the European invaders? Were there any that were close and might have just needed a bit more momentum or strokes of luck to have achieved success? What might have happened if such had occurred, and what sort of culture might such a state that comes out of such a revolution look like, depending on when exactly said revolt occurs?
 
I don't classify that as Successful. They were free until the leader who had lead them to victory was dead. Then the Spanish came back in and retook control.
 
From New Mexico Office Of History
Popé is revered in New Mexicoas the leader of the Pueblo Revolt of 1680. Pueblo scholars refer to him as the one who carried out the first successful American revolution against a foreign colonial power, Spain. Popé (Ripe Pumpkin) was from Ohkay Owingeh (known today as San Juan Pueblo) and, as best can be determined, was born around 1630.

. It took a unique individual to orchestrate the Revolt across two dozen communities who spoke six different languages and were sprawled over a distance of nearly 400 miles - from Taos at one end to Hopi villages at the other. Pueblo people were prohibited from using horses. Moreover, during Spanish rule they were not allowed to use guns of any kind.
 
Well, if anyone is interested, the revolt of Juan Santos Atahualpa was the most successful of the Native revolts in Peru. It was never truly defeated, and ultimately, it was Juan Santos' death what ended the rebellion as they pacified themselves without his mesianic figure.
 
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