Catholic England:
My claim is that all you need to avoid Henry VIII kick-starting the English Reformation is to have Catherine die a few years earlier. The best guess is that she died of cancer, so my POD is that this cancer progresses more quickly.
By the time Henry hears back from the Pope that an annulment won't be granted, it doesn't really matter, because Catherine died in 1531. Henry marries Ann who produces 2 male heirs (Henry IX, Elizabeth, Edward, and Catherine), and because of the advice of Henry's Catholic advisors, tolerates Henry's womanizing.
Henry pushes his absolutism but not to the point where he breaks with Papal Authority, and remains a Defender of the Faith. By having heirs, his stress eating and spending are tempered and he establishes a strong Tudor England.
Independent Habsburg Netherlands:
An immediate butterfly of this timeline is that Charles V produces an additional male heir - Joanna of Portugal is instead born John. When Charles, weary from managing a large empire, abdicates near the end of his life, he gives the Habsburgs Netherlands to John, and it is recognized as an elector in the HRE and, following the loss of HRE sovereignty (in a 30 YW equivalent or when the Netherlands converts to Protestantism and secedes), becomes a kingdom.
My major question is: how likely would it be that Charles V carves out the Netherlands as an independent domain for John (in the Netherlands, Johannes). Given that Charles split his realm between Spain (Philip) and the HRE (Ferdinand), could Johannes be given the Netherlands?
How would Charles strategy in the Netherlands be affected by having an additional son that he attends to create a crown for? Would he be more aggressive in the Netherlands to seize strategically important areas?
How does France react, at first to Catholic / Habsburg-aligned kingdoms on all sides, and then to an independent Netherland-Rhineland to the north?