I am always a bit reluctant to ponitificate about this issue cos it is impossible to prove either way
Jacquetta Woodville had at best guess anything up to 14 children.
Of her sons - Anthony was married twice and had only one illegitimate child (his first wife had no children by her first husband so it may have been on her side), Lewis is thought to have been the eldest boy but died young, Lionel went into the church, John married a much older woman and was executed by Warwick, Richard and Edward never married which given their circumstances for most of their adult life is not surprising.
The Woodville's finances were precarious - the 1st Earl's estate was modest most of their day to day living came from what of her dower as Duchess of Bedford she'd managed to keep but it was life interest only and on her death reverted to the crown (they failed to convert most of her assets to enable them to pass to her children) this meant her sons had to marry well or not at all quite frankly - with the exception of Anthony Edward IV did very little for his wife's brothers.
Of her daughter's Elizabeth Woodville had 12 children (of which all but two lived to adulthood), Anne Woodville had four children that lived to adulthood, Jacquetta Woodville had one surviving child, Eleanor or Joan married but had no recorded issue, Margaret had four children, Mary had one (but might have died in childbirth), Catherine had four.
Given that even with high ranking aristocrats stillbirths and miscarriages were not usually recorded - its hard to read much in any of the above - but the majority of Jacquetta's daughter's proved fertile - Catherine had four children in around five years for example.
As to her grandchildren - well the York girls seem to have had issues but given the rate of infant mortality and the fact the higher you were socially the more medical intervention you got and that was often the real cause of the mother or the child's death - it is perhaps not surprising.
I have read that the problems of infant and maternal death actually increased during the 16th Century so perhaps the Tudor's were just unlucky in their medical care rather than cursed with any hereditary problem.
In terms of the Tudor's Margaret and Mary had little problem conceiving - Margaret had eight recorded children by three husbands of which only two survived to adulthood (both of which had issue though Margaret Lennox suffered a number of miscarriages), Mary Tudor had four of which two survived (and both her daughter's had issue) - Henry VIII his six wives and one known mistress had at least 12 pregnancies leading to four surviving children (though both his sons died in their teens)