Muslims played a pretty big role in the Ming government and there were numerous Muslim generals in the Red Turban Rebellion that overthrew the Yuan, at least one of whom was allegedly adopted by the Hongwu Emperor. The Hongwu Emperor's wife, Empress Xiaocigao/Ma Hou, also had a common Muslim family name, though I haven't been able to confirm if she was of Hui extraction. There was also a rebellion in Fuijan led by Muslim soldiers during the Red Turban Rebellions, though they were suppressed by Yuan loyalists.
The general idea I have is that the Ispah Rebellion is more successful and links up with the Ming. Towards the end of, or shortly after, the Red Turban Rebellion Zhu Yuanzhang, the OTL Hongwu Emperor, dies and is succeeded by one of his Muslim generals, either Mu Ying, his adopted son, or Lan Yu, who was accused of trying to rebel IOTL though that might have just been an excuse for a purge. Timur dies earlier, resulting in a much more prosperous Iran and Central Asia able to exert greater economic and cultural influence on China and a stronger Northern Silk Road. During their wars with the Northern Yuan the Ming are able to subjugate the Muslim Öljei Temür Khan and prop him up as a vassal, leading to the Islamisation of Mongolia and Eastern Siberia and a more secure northern border.
The general idea I have is that the Ispah Rebellion is more successful and links up with the Ming. Towards the end of, or shortly after, the Red Turban Rebellion Zhu Yuanzhang, the OTL Hongwu Emperor, dies and is succeeded by one of his Muslim generals, either Mu Ying, his adopted son, or Lan Yu, who was accused of trying to rebel IOTL though that might have just been an excuse for a purge. Timur dies earlier, resulting in a much more prosperous Iran and Central Asia able to exert greater economic and cultural influence on China and a stronger Northern Silk Road. During their wars with the Northern Yuan the Ming are able to subjugate the Muslim Öljei Temür Khan and prop him up as a vassal, leading to the Islamisation of Mongolia and Eastern Siberia and a more secure northern border.