Northern England even during the time of Æthelstan of England was quite resistant to centralization but William's Harrying of the North put that much to end.
The closest is the Jacobite movment, which didn't want to split but restore James II (and III, and Charles) to the rightrful thrones of England, Ireland, and Scotland. Since they refused the Union Acts, a success in Scotland (which is plausible) effectively is a separatist effect