This is outright wank. The only directly ruled territory I see as feasible beyond OTL is South Italy, Sicily, and Malta along with a few more vassal states. How are the Ottomans supposed to hold Iran?

As was noted, they literally have no one in position to stop them. HRE and Hungary are distracted by Bohemia, France and England are still in the Hundred Years War, Spain has yet to come about, and the Italian states are at an extremely weak phase. As for Persia, it's largely ruled by weak tribal confederations and even IOTL, the Ottomans managed to conquer a large portion of it anyway. Conquering the rest of the OTL Safavid Empire plus annexing Italy and Granada would essentially be the only additional conquests they'd be doing that they didn't manage historically and with no real enemies in their path for the time being, is such really that far fetched? If it helps, I can definitely seem settling on making Hungary and the Romanian states vassals instead of direct conquests in order to achieve the "Justinian's Empire plus the Safavids" borders I outlined earlier.
 
Persia only became shiite in a large scale during the 1500's. So i doubt the ottomans will have much of a problem subduing them.
Isn't it possible for the Ottomans to reach a point of over-extension if they conquer Persia (and all the other places mentioned) to quickly?
Perhaps initially vassalizing the Zargos and Mesopotamia and integrating them later like what occurred in the Balkans could occur?
 
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