There were somewhere on the order of a dozen crusades called for over the course of the 1400s, but most went unanswered, and the few that came to anything came up just a bit short, often to the point of bad luck. In my opinion, any time before Mehmed II takes Constantinople the Ottomans are in serious danger of falling apart. They are an empire without a significant navy divided in two by a semi hostile bosporus and the Venetian vulture looking for anything that they can profit from. Worse still, approximately half of their people if not more are still Christian and definitely not Turkish. Mehmed II fixes the most important problem by taking Constantinople, adding more Islamic turkish subjects through his eastern conquests, and creating the beginnings of the Ottoman navy as a dominant force. He also did a good job of milking the idea that he was better for Orthodoxy than the Pope by naming his own patriarch of Constantinople and keeping him in his pocket. Without all of this, the Ottoman Empire is still quite fragile in my opinion, and a significant defeat by westen forces that is actually followed up on could very possibly cost them their lands in Europe.
There quite good reasons why the significant defeat you name failed to materialize IOTL. Not impossible, a decisive blow from the West in the immediate aftermath of Ankara would have been very, very destabilizing form the Ottomans. But there was nobody willing and able to deal that blow, also because the last attempt at it had just failed quite badly at Nicopolis.