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How fast did the epidemics of smallpox and other diseases spread once the Europeans reached the New World? Did they pretty much spread throughout the New World on their own due to contacts between native cultures, or did the population density or natural barriers prevent them from reaching certain regions until Europeans had settled those regions?

Hypothetically, let's say a group of Europeans arrives in Eastern Canada some time in the early part of the second millenium. No Europeans arrive for about 400 years. How far have their diseases spread?
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