Most "US states go there own way" threads deal with the Constitution not going into effect. Most common complaint is- the Articles would remain in effect and a centralization would occur down the road.
Now, what if we say the Articles arent accepted in the first place? It had to have unanimous ratification and Maryland held out until New York and Virginia gave up their western claims (NY claimed every thing north of the Tennessee River, east of Illinois River, and south of Great Lakes). What if Virginia says- nope. And Maryland says- ok, no to Articles.