Since I took the USA out of the First World War that means this questions is part of the tangled web of butterflies taking flight thereafter. So I have even more impacts to the cultural landscape. And my initial thought is that would potentially derail the national level prohibition but as other point out it leaves the state and local efforts to control or ban alcohol. The USA, as far as I can tell, had licensing laws, prohibition "dry" or almost no control "wet".
My observation is that it would be mostly rural, mostly protestant (tending towards what we can call evangelical) counties and states that pass more restrictive or prohibition laws. This would cover much of the South, some portion of the Great Plains, tending into the Midwest, touching the West and New England. Most of the USA was already under some form of local prohibition and few places already dry up to state-wide. That trend might continue so we see more jurisdictions going dry or tightening licensing and a few states might go outright dry. For a lot of America it might not change, and for cities they attract more people and we hasten the decline of farm life. And it might cycle back to be a renewed fight from a yet more militant and oddly distinct rural dry culture versus the wet urban city folk. And who knows how it alters the vague Republicans are dry (boring/conservative) and Democrats are wet (fun/liberal) dynamic where FDR does not repeal what does not exist.
In this era the Supreme Court was rather reluctant to let Congress exercise its ambiguous powers under the Commerce Clause so I think the 18th Amendment was the result, only an amendment could assure Congress and the federal government could enact prohibition. So on the obverse Congress can do little to effect the wet versus dry states. We know that alcohol content was higher since transport was longer and not refrigerated, something for say beer might change on its own. If Whisky can still be imported we don't see the gutting of Irish and Scottish distilleries, mitigating the economic impacts in those places. We see more federal liquor tax revenue so less need for tariffs so another straw withdrawn from the Depression economics. Start pulling at the strings and I think we underestimate how far the changes could go.
We know that beer and wine are bigger in the catholic German and Italian communities, spirits big with the Irish, all groups targeted as not being White, Anglo-Saxon or Protestant enough. With no prohibition the white washing of those communities might be less, it should be under my scenario, so we see German, Italian and Irish cities still have beer, wine and whisk(e)y, along with language, cuisine and cultural influences. That sets America up for a more diverse "white" cultural and who knows how much more diverse overall. For example with a more distinct catholic Italian community, would the Spanish speaking catholic populace be less "foreign" or viewed as a bigger minority of South European? We might see the Irish community even less Anglophile and favorable to London, impacting foreign affairs.
Without the gangland violence we have less need for the FBI, let alone ATF, we have smaller federal police or responses to problems. We do not get Great Gatsby or the modern mixed cocktail or more! Jazz was popular, black musicians played it in Speakeasies, this puts them and blues into the wider culture, that alters country, folk and bluegrass/gospel to beget rock-and-roll. Prohibition everywhere impacts the women's liberation thread, homosexual rights thread, race-relations, music, literature, cinema, and so many more threads as these interact upon one another.
At the end I have slowly come to see America in far grayer trends, impressions of its culture, such that in the America I think of post-First World War, without Prohibition, and even more knock-ons. America becomes only barely familiar to me, some familiar rocks in the shifting different unfamiliar sands. I would not underestimate that given 50 or 100 years, this paradigm shift does not erase so much we think we think we are that even my thoughts here are really not weird enough.
