No more Hawkins and Drake

http://www.uni-mannheim.de/mateo/camenaref/cmh/cmh315.html

An expedition led by John Hawkins and his nephew, Francis Drake, consisting of five small vessels from Plymouth, was caught in September, 1568, by a greatly superior Spanish force at San Juan de Lua on the Mexican coast, and overwhelmed, in violation, as it was asserted, of a compromise that had been arranged. Two of the smallest vessels alone escaped with Hawkins and Drake ; and thenceforward the latter devoted his great genius, skill and boldness, to harrying Spanish commerce from the seas.

What would the effects on Elizabethan naval power be if these 2 fell in Spanish hands?
 
Outside of the over-hype that surround them I don't think they never did anything that could not be done by any of the sea thieves that were sailing from England at that time.
 
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