The Pharisees came into existence only after the Hasmonean state gained independance.
Anyway, the Jews were Hellenized to a degree. They spoke Koine Greek and many adopted Greek names. But I don't see a majority being fully Hellenized. Without the Maccabbean revolt there is one less thing the Seleucids have to worry about(during a rather long time, the Seleucids were occupied with that region and Hasmonean leaders had influence within the Syrian court. Also, the Romans supported the Hasmoneans so any conflict with the Hasmoneans means conflict with the Republic).
I guess it could delay the Seleucid's fall, but the Southern Levant will break up from the rest of the Seleucid Empire after a civil war(very common in that era with the Syrians) and with it Judea will probably gain independance of some sort(though probably not under the Hasmoneans, who started out as a minor priestly family from some mildly-known countryside town).
In short, I think it will remove the Jews' political power for at least 40 years, and give a minor boost - barely enough to save it - to the Seleucid Empire.