One of the things that helped to foster the Second Great Awakening was the "Alcoholic Republic". When cities were first founded in the US, they were founded as often as possible on freshwater sources. Obviously fresh water is important. But an early and integral element of Americanism was the expansion westward. Pioneerism meant that cities in the moving West were usually not as big as those in the more established East and less likely to have available fresh water.
There is a reason sailors are infamously drunkards. Its because in the absence of good fresh water and with the sharing of common water sources, diseases are bred. The solution is to drink alcohol. Alcohol is mostly water, meaning it largely serves to hydrate while simultaneously destroys bacteria, meaning it helps to prevent disease.
Americans have always drank alcohol in favor of water, even the Puritans drank. The problem with this is obvious - it's easy to get drunk. This is why American beer is notoriously weak, it was never intended to get you drunk, but to serve as a clean substitute for water. People still got drunk often though and the early decades of the United States saw an widespread alcoholic problem (hence, the "Alcoholic Republic"). Perhaps most notably, Franklin Pierce had a drinking problem his entire life.
This predominance of alcohol and the problems it produced did a lot to inspire a strong prohibitionist movement in the US. Prohibitionists usually latched onto another near-universal aspect of early Americanism, the Bible and used that to campaign against alcohol. As a result, most prohibitionists were biblethumpers as well and helped contribute to the Second Great Awakening.