Three ways to go.
1. No Temuchin, no Mongol conquest of the Silk Road, no gunpowder to Europe, no expensive cannon, no large/centralized nation states, no extra resources to attempt sea routes to India/China, etc. Europe stays feudal another seven hundred years and we are reading this by candle light in a monastory in Brittany.
2. All the Europeans discover/develop trade relations with the Indians at the same time, say, when Columbus doesn't make it back in one piece and one or more members of his crew in a small boat get back and find their way (with convincing souveniers like gold, American spices, other plants and animals) to first Ireland, then Scotland, then England, then the Netherlands, then France, and are captured by Arab corsairs. All the Arab/European nations have trading missions instead of conquest expeditions and the Indians play them off against each other.
3. Columbus makes it to the Americas and doesn't make it back because of a smallpox epidemic caused by his hauling along an unexpectedly sick cabin boy. The remaining and more disease resistant Indians now have iron, gunpowder, literacy, coinage, sailing ships, some European crops, etc. You really have to bring honeybees along on the ships to get proper European crop productivity, and goats for dairy/wool/meat/traction capability.