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After no luck with the Search function here, I’m posting a general question for everyone: Does anyone recall a TL revolving around or at least incidental to the introduction of new diseases from Native Americans to Europeans, on a scale approximating that of the damage caused by European disease in the Americas?

Some estimates claim that European diseases killed up to 95 percent of the native populations in the first 100 years or so of contact. I’ve had a scenario running around in my head where the Indians give as good as they get, involving a two-way disease trade between Europeans and indigenous Americans. I know that most of our now-common diseases came from domesticated animals, but a few, like yellow fever IIRC, came from incidental contact with wild species. (Monkeys in the case of yellow fever.) So I’m envisioning one or more endemic diseases among the native population which Europeans have no immunity to, and which affects Eurasia on a similar scale as, say, smallpox and measles did in the Americas.

Has such a timeline ever been explored here? What would be the impact of a mystery plague that killed even more people in Europe and Asia than the Black Death?
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