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For all the more advanced weaponry and resources of the Europeans it was really diseases that played the by far biggest factor in the down fall in population at least of the Native Americans.

If instead of 80-90% of natives succumbing to diseases it was more around the low end for the black death in Europe of 30% of the population succumbing to disease. How would colonization have gone about with the millions of more natives in the continent than IOTL?
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