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In what is today the Southeast of the United States in the 1500s, there were highly advanced societies that were the ancestors of today's Cherokee and Choctaw tribes. Suppose that these ancestral societies had by the time De Leon came calling built something like Opechecanough in Virginia or Hiawatha in the North. Suppose that there is a league of southeastern native Americans that could use the formidable military power of that alliance against the too-curious white man and knock him loose. How much in general would a pan-Mississippian alliance impact the survivors once the plagues of Europeans start the decimation? What impact would a greater sense of unity among American aborigines have when *Tecumseh or someone like him emerges among them? Could we see a pan-American aboriginal alliance to check the U.S.? How does U.S. Native alliances if they can be built affect the First Nations in Canada?
Some answers would be appreciated for a TL I'm working on.