However this ATL America would only be interested in affairs in the Americas, it would be isolationist in relation to affairs in Europe, Asia and Africa, really they just want economic acess...
If America wants economic access to Europe, Asia, and Africa, it really doesn't seem isolationist at all.
Can Britain and its Empire build Armed Forces than that not only protect Britain and its Colonies in Europe, Asia and Africa from Germany, Japan and their allies and defend Canada and the British Carribean from America, all this without lend-lease?
Doubt it.
However, if it's the US that abrogates the WNT in the 20s, rather than Japan that doesn't sign LNT2 in 1936, then don't expect WWII in the same form in any way.
Even if Tokyo allowed American acess to the Chinese economy?
More that, if the US embargoed trade with China in the way that it did with Cuba after Castro took over, then Japan would consider that just possibly the US would not need curbstomping. A pullout from the Philippines which celebrated independence and did
not maintain a military presence and economic dependency would probably cement that impression - in particular if it was clear that Manila would have no US aid in repelling a Japanese conquest.
Also if Pearl Habour was still done, would Tokyo see that it is even more stupid to attack the United States than OTL?
Ifs and butterflies.
If Japan is going to have to go to war with the US to ensure its ability to prosecute the war with China (e.g. no US trade embargo, no Japanese hard currency shortfall to purchase oil with), then Japanese doctrine demands a Mahanian decisive battle with the US Pacific Fleet. Japanese flawless victory will then have the US sue for peace and acknowledge Japanese awesomeness.
If Japan is going to have to destroy the US Pacific Fleet, then if and only if a jingoist US president forward-bases the battleships at PH instead of boringly and safely on the West Coast will there be a PH attack.
The things that will convince Japan of this sort of thing include: sending the China Lobby (inc. OTL SecWar Stimson) to the gulags; abandoning the Philippines, Guam, Wake, and Midway; pulling out of the foreign concessions in China; and not building a Two-Ocean Navy.
If Vinson gets a giant bucket of money to try to outbuild the RN, then the IJN will probably get the screaming heebie-jeebies about US intentions regardless though.
Why would America (a isolationist one) be interested in ruling regions in Asia that are very likely to remain Non-White for a very long time?
Like I said there is one rule for the America's and one rule for everyone else...
The short answer is
cui bono. There is a lot of money to be made for the Americans who historically invested in the US's exploitation of China and the Philippines, and those rich and influential individuals will attempt to curry governmental favor and push US policy towards interventions in their areas of interest, to allow them to continue to make money (cf. Dole and the Banana Wars). Now, if the NatSocUS decides that that's not in keeping with National Socialist thought and has those pro-intervention folks all shot, then it's a more viable course to chart.
Timing however remains everything. When does the US change direction?