Having flirted with several little TL's over the past few months, I'm going to poll which should be my first major TL
1.) One More Glass
A drunk Senator Ted Kennedy passes out on the couch after consuming too much alcohol at the Boiler-Room reunion party on July 18th 1969 meaning that the Chappaquiddick Incident never happens. This leads to EMK 1972 and beyond...
2.) Silver Foot Reborn
Ann Richards defeats George W. Bush for a second term as Texas Governor in 1994 meaning that W. retires from politics and eventually becomes Commissioner of Baseball. The 2000 election turns out a whole lot differently with Al Gore becoming President and a wide-ranging 2004 GOP field.
3.) One Hell of an America
Air Force One is shot down by an improvised SAM while leaving Florida on 9/11, at the same time both the White House and Congress are hit by separate planes killing the Vice President, Speaker and President pro tem leaving Colin Powell as the new President to lead America through it's worst crisis since Pearl Harbour.