Most devastating serf rebellion possible?

Serf rebellions were common in the Middle Ages, but usually got put down brutally, without causing much disruption to the feudal system. What rebellions could disrupt the system and collapse the power structure in a country? Primarily looking at Europe here.
 
Looking at Europe specifically, the Hussites were a pretty big deal in the 15th century, lasting from 1419 to 1434 they did quite a lot of damage to the Holy Roman Empire, the Kingdom of Bohemia especially, they also beat back several crusades and intervened in other nations' affairs until they were finally placated. I'm not sure if they qualify as explicitly a peasant rebellion but they're the largest one I know of in the late medieval period. (They also used a lot of guns).
 
Looking at Europe specifically, the Hussites were a pretty big deal in the 15th century, lasting from 1419 to 1434 they did quite a lot of damage to the Holy Roman Empire, the Kingdom of Bohemia especially, they also beat back several crusades and intervened in other nations' affairs until they were finally placated. I'm not sure if they qualify as explicitly a peasant rebellion but they're the largest one I know of in the late medieval period. (They also used a lot of guns).
They had a strong religious component, but they do count somewhat. What about purely peasant revolts- anything that could become massive enough to totally cripple the nobility in a nation?
 
The French revolution ?

Serfdom per se was mostly gone by then I believe.

The Time of Troubles? The Peasant's War?

Of course, a part of the problem is that peasant revolts were usually either small scale (satisfied with burning the local manor houses and tax/census/property records), or ended up conscripting local notables with military experience as their leaders.
 
The German Peasants War is probably the most significant in numbers that I know of in Europe.

If it were to succeed, who knows what it could've become (I actually have a long-ish timeline idea where they play a significant role in reshaping Europe).
 
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