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It seems that the big Mosquito borne illnesses largely established themselves in the America’s through the Slave Trade.

So, had we avoided the Slave Trade (which has obviously been discussed), how likely is it for most of these diseases (Malaria, Yellow Fever, etc) to pop up? And would their worst forms make it?

And if they can be avoided, how big is that butterfly? I would imagine that close to a nine digit figure for lives is saved. That colonization is more widespread in tropical places and exploration of the interior of South America is more widespread in the early days.

Even if the introduction of these diseases is just delayed a half a century or two, how impactful is that?
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