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What are the minimum amount of nuclear weapons required to effectively destroy or set back by a few centuries global civilization as we know it?

Note this isn't asking how many nukes to kill everyone just how many to send humanity back to the Dark Ages if we're lucky.

These are nuclear strikes in and of itself. So no other countries can fire back at their enemies because they suspect they're responsible. (Pakistan/India, US/Russia/China, Israel/Iraq etc.)

What would your list of targets look like?

One on my hypothetical list would be the Houston Shipping Channel. Destroying that alone would screw up the US economy.
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