Married by May 1514

In 1505, negotiations began for the marriage of 11-year-old Princess Mary, the daughter of King Henry VII of England, to five-year-old Charles, the grandson of King Ferdinand and Queen Isabella of Spain.
As the victory of Thérouanne was celebrated, it was agreed that Charles and Mary should be married by May 1514. Charles and Mary did not marry.

Suppose in May of 1514 Charles of Spain marries Princess Mary. What happens then?
 
So Charles of Spain, is Charles of Ghent then?

It means that Henry VIII is now the brother-in-law to the King of Spain and the Holy Roman Emperor. This would make their relationship strained when the Henry VIII founds the Protestant Church of England. It may lead to a religious war between Charles and Henry.

It also means that Lady Jane Grey would never have come to the throne for nine days, because Mary Tudor would never have married Charles, Duke of Suffolk.
 
@ LeopoldPhilippe: you forgot to mention he was the grandson Maximilian of Austria (Holy Roman Emperor) and Mary the Rich of Burgundy.

AFAIK Maximilian was also heavily involved in the future of his grandchildren. He also favoured this English match for Charles. One of the reasons he didn't specify, which of his grandsons would marry Anna of Bohemia & Hungary.

Maybe Mary Tudor would eventually be more happy in this marriage with the younger Charles, than she IOTL was in her marriage with Louis XII, who was 34 years her senior.

@ TheBrunswickian: by 1514, we can't really predict, what will happen. Perhaps Catherine of Aragon dies and Charles and Mary manage to marry Henry to one of Charles's sisters?
Henry VIII does not need to become a Protestant; one might even prevent this, if Henry also has a legitimate male heir (preferably a few).
 
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