Maria Porphyrogenita as heir to Manuel I

What if Manuel Komnenos had had no son (OTL's Alexios II) in 1169 and was left with Maria Porphyrogenita as his sole heir? Would she be able to rule on her own accord?

Thinking of doing a TL with a "Byzantine" equivalent of Tamar the Great of Georgia and have found Maria to be such an intriguing personage. Obviously she was the leader of the "anti-Latin" faction in Constantinople following her father's death in 1180 and led the plot against Maria Xene/The Protosebastos Alexios...she appears to have been ambitious, well educated and highly driven to rule.

She will obviously have to marry a suitable spouse to rule alongside her, who besides OTL's Renier-John of Montferrat would have been a good candidate? Would the Montferrat connection have strengthened her position with the aid of Renier and Conrad, the OTL Crusader?
 
Apparently, apart from Bela of Hungary, Maria was considered as a bride for William II of Sicily and/or one of Henry II's sons. Regardless, whoever she marries, she'd have to contend with any of the male Komnenoi like Andronikos or her cousins, John and Alexios, sons of Manuel's older brother (also named Andronikos).
 
I figured that she, even as Porphyrogenita, would have to contend with many other family members' conspiracies. Would Renier of Montferrat been able to make it as Emperor? Perhaps his able brother Conrad arrives (and stays) in Constantinople to help Maria and Renier consolidate their reign?

IF William II of Sicily marries her, would he have come to Constantinople? I'm trying to imagine William as a basileus...
 
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