So, this is something I've been considering recently. Otl Maria Francisca of Nemours, married Pedro II of Portugal in 1668 and gave birth to a daughter in 1669, but after that had no more children. When she died in 1683, Pedro remarried and had a fair brood of children, so, my question is this, what changes if Maria Francisca is able to have more children after 1669, and this includes a son and another daughter?