In December 1458 at
Casale, she married her first husband,
John IV, Margrave of Montferrat, the son of
John Jacob of Montferrat and Joan of Savoy. He was a
condottiere for the
Republic of Venice during the
Wars in Lombardy which were a series of conflicts fought between
Venice and
Milan, and their various allies.
Margaret brought a dowry of 100,000
scudi, and in return received
Trino,
Morano,
Borgo San Martino, and
Mombaruzzo. The marriage was childless, although he fathered several illegitimate children. He died on 19 January 1464, leaving her a widow at the age of twenty-five.