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WI Manuel Komnenos had managed to have a son with his first wife, Bertha of Sulzbach? Let's say that, for whatever reason, things go differently and the Maria Komnene of OTL is born a boy, who we'll call *Alexios II; assuming Manuel dies in 1180 as in OTL, *Alexios II will be 28 in this scenario.
What will the effects of this be? Obviously the butterflies are going to be immense, but I imagine that the Byzantines are going to fare far better with a capable adult on the throne.
By the way: I am in no way an expert on the subject of the Byzantine Empire, so please, be merciful if I am assuming too much with such a POD.